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Laboratory of Transcriptomics


E-mail: [email protected]
Principal Investigator: Yuan-chi (Andrea) Teng, Ph.D.

EDUCATION

Ph.D.｜Sep 2010-Jan 2017  Program in Molecular Medicine, School of Life Sciences, National Yang-Ming University, Taiwan

M.S.｜Jul 2005-Aug 2007   Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taiwan

B.S.｜Sep 2001-Jun 2005    Department of Life Science, Tunghai University, Taiwan

 Ta-Hsien Lin

PROFESSIONAL CAREER

Assistant researcher fellow｜Mar 2022 – present  Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan

Postdoctoral fellow｜Aug 2021 – Feb 2022  Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan

Postdoctoral fellow｜Mar 2017-Dec 2017 & Jun 2020-Jul 2021  Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan

Postdoctoral fellow｜Jan 2018-Dec 2019  Research Center for Gene Therapy, Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil

Grants

  • New layer of developmental regulation in retinal axonogenesis: the m6A RNA modification (NSTC 112-2311-B-075-001 / PI)
  • New layer of developmental regulation in retinal axonogenesis: the m6A RNA modification (II) (NSTC 113-2320-B-075-011 / PI)

SPECIALTY

  • Pre-clinical mouse model (genetically modified mouse)
  • Developmental biology
  • Transcriptomic analyses

TECHNICAL SKILLS

Mouse Genetics, molecular pathology, molecular biology, systemic biology, NGS

AWARDS AND HONORS

  • (2018) 17th Japanese Association for Laboratory Animal Science [International Award, invited oral presentation]
  • (2018) 14th Veterans General Hospitals University System of Taiwan Excellent Research Article Award [Second prize, Teng et al. J Pathol (2018)]
  • (2017) 15th Conference of the Chinese-Taipei Society of Laboratory Animal Science [First prize, oral presentation]
  • (2017) Outstanding Research Article Award of the Prof. Juei-Low Sung’s Research Foundation
  • (2017) Doctor Thesis Competition of National Yang-Ming University [First prize, oral presentation]
  • (2017) The 25th Symposium on Recent Advances in Cellular and Molecular Biology [Dr. Chien-Tien Hsu's Award, oral presentation]
  • (2016) 14th Conference of the Chinese-Taipei Society of Laboratory Animal Science [Excellent award, oral presentation]
  • (2016) Cold Spring Harbor Asia Conferences: Liver Metabolism, Diseases and Cancer [Fellowship award, poster]
  • (2013) Mini-symposium on Mitochondria and Aging [Bronze prize, poster]
  • (2012) 8th Veterans General Hospitals University System of Taiwan Poster Competition [First prize, poster]
  • (2012) Macky International Symposium: Mitochondrial Dysfunction and Aging-related Diseases [poster award]
  • (2011) 11th Conference of the Chinese-Taipei Society of Laboratory Animal Science [Excellent award, oral presentation]
  • (2011) 7th Veterans General Hospitals University System of Taiwan Poster Competition [Second prize, poster]
  • (2007) Dean of School of Life Science Prize, National Yang-Ming University
  • (2007) National Yang-Ming University Annual Thesis Competition [Excellent Award, poster]
  • (2005) Luce Scholarship, Tunghai University
  • (2003) Prof. Chen Fung-shien Scholarship, Tunghai University
  • (2002) Prof. Chen Fung-shien Scholarship, Tunghai University

PUBLICATIONS

  1. YF Chen, YC Teng, JH Yang, CH Kao, TF Tsai. Cisd1 synergizes with Cisd2 to modulate protein process by maintaining mitochondrial and ER homeostasis. [manuscript under revision in Aging (Albany NY)] [IF=3.9]
  2. YC Teng, YL Chung, YF Chen, YH Hsu, N Itoh, TF Tsai. Skeletal muscle is a master regulator in adiposity and systemic metabolism during accelerated aging. [under revision in EMBO rep; IF=6.5]
  3. HC Hong*, JH Lin*, YC Teng*, CH Kao, PY Wang, BW Song, TF Tsai. A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (SCA22) by impairing ER and Golgi functioning. (2025) J Pathol, 265: 57 [IF=5.6] *, co-first author
  4. CC Hsu, HK Chuang, YJ Hsiao, YC Teng, PH Chiang, YJ Wang, TY Lin, PH Tsai, CC Weng, TC Lin, DK Hwang, AR Hsieh. Polygenic Risk Score Improves Cataract Prediction in East Asian Population. (2022) Biomedicines, 10(8):1920 [IF=3.9]
  5. CH Yeh, ZQ Shen, YJ Chou, TW Wang, CH Kao, YC Teng, TK Yeh, CK Lu, TF Tsai. Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice. (2022) J Biomed Sci, 29: 53 [IF=9.0]
  6. RH Chou, MY Yang, YP Yang, CA Yeh, WY Lai, TW Lin, YC Teng, SC Hsieh, ML Kung, HH Hsieh, HS Hung. Evaluating the biocompatibility and biological performance of FePt-decorated nano-epoxy nanoparticles in mesenchymal stem cells. (2021) J Chin Med Assoc, 84(12):1109 [IF=1.9]
  7. PC Teng, Y Liang, AA Yarmishyn, YJ Hsiao, TY Lin, TW Lin, YC Teng, YP Yang, ML Wang, CS Chien, YH Luo, YM Chen, PK Hsu, SH Chiou, Y Chien. RNA modifications and epigenetics in modulation of lung cancer and pulmonary diseases. (2021) Int J Mol Sci, 22:10592 [IF=4.9]
  8. CY Lee, CH Huang, E Rastegari, V Rengganaten, PC Liu, PH Tsai, YF Chin, JR Wu, SH Chiou, YC Teng, CW Lee, Y Liang, AY Chen, SC Hsu, YJ Hung, JR Sun, CS Chien, Y Chien. Tumor necrosis factor-alpha exacerbates viral entry in SARS-CoV2-infected iPSC-derived cardiomyocytes. (2021) Int J Mol Sci, 22:9869 [IF=4.9]
  9. YL Huang, ZQ Shen, CH Huang, YC Teng, CH Lin, TF Tsai. Cisd2 protects liver from oxidative stress and ameliorates western diet-induced nonalcoholic fatty liver disease. (2021) Antioxidants, 10:559 [IF=6.0]
  10. YC Teng, AL Porfírio-Sousa, GM Ribeiro, MC Arend, LDS Meirelles, ES Chen, DS Rosa, SW Han. Analyses of the pericyte transcriptome in ischemic skeletal muscles. (2021) Stem Cell Res Ther, 12:183 [IF=7.1]
  11. ZQ Shen, YL Huang, YC Teng, TW Wang, CH Kao, CH Yeh, TF Tsai. CISD2 maintains cellular homeostasis. (2021) Biochim Biophys Acta-Mol Cell Res, 1868:118954 [IF=4.6]
  12. YC Teng, JY Wang, YH Chi, TF Tsai. Exercise and the Cisd2 Prolongevity Gene: Two Promising Strategies to Delay the Aging of Skeletal Muscle. (2020) Int J Mol Sci, 21:9059 [IF=4.9]
  13. CP Yang, WS Yang, YH Wong, KH Wang, YC Teng, MH Chang, KH Liao, FS Nian, CC Chao, JW Tsai, WL Hwang, MW Lin, TY Tzeng, PN Wang, Mel Campbell, LK Chen, TF Tsai, PC Chang, HJ Kung. Muscle atrophy‐related myotube‐derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. (2020) Aging Cell, 00:e13107 [IF=8.0]
  14. WP Wang, JY Wang, WH Lin, CH Kao, MC Hung, YC Teng, TF Tsai, YH Chi. Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. (2019) Aging Cell, 19:e13090 [IF=8.0]
  15. CH Yeh, ZQ Shen, SY Hsiung, CY Wu, PC Wu, YC Teng, YJ Chou, SW Fang, CF Chen, YT Yan, LS Kao, CH Kao, TF Tsai. Cisd2 is essential to delaying cardiac aging and to maintaining heart electromechanical functions. (2019) PLoS Biol, 17: e3000508 [IF=7.8]
  16. YL Huang, ZQ Shen, CY Wu, YC Teng, CC Liao, CH Kao, LK Chen, CH Lin, TF Tsai. Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging. (2018) Aging Cell, 17:e12705 [IF=7.8]
  17. YC Teng, JC Neo, JC Wu, YF Chen, CH Kao, TF Tsai. Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice. (2017) J Pathol, 241:463 [IF=5.6]
  18. YC Teng, ZQ Shen, CH Kao, TF Tsai. Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes. (2016) World J Gastroenterol, 22:300 [IF=4.3]
  19. SH Wang, SH Yeh, CW Shiau, KF Chen, WH Lin, TF Tsai, YC Teng, DS Chen, PJ Chen. Sorafenib Action in Hepatitis B Virus X-Activated Oncogenic Androgen Pathway in Liver through SHP-1. (2015) J Natl Cancer Inst, 107: djv190 [IF=13.757(2011)]

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