EDUCATION

2008–2014    Ph.D., Program in Speech and Hearing Bioscience and Technology, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA

1993–2000    M.D., Taipei Medical University, Taipei, Taiwan

2014–2016  Postdoctoral Research Fellow, Harvard Medical School/Massachusetts Eye and Ear Infirmary ,Boston, MA, USA
2006-2008   Fellowship, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden 
2005-2006   Fellowship in Neurotology and Skull Base Surgery, Department of Otolaryngology– Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
2001-2005   Residency: Otolaryngology- Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan

PROFESSIOANL EXPERIENCES

Primary appointments
2017-present    Attending Doctor, Department of Medical Research, Taipei Veterans General Hospital, Taiwan
2023- present   Professor, School of Medicine, National Yang Ming Chiao Tung University, Taiwan  

Secondary and adjunct appointments
2017-present    Research Director/ Attending Surgeon, Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taiwan
2023-present    Professor, Institute of Brain Science, National Yang Ming Chiao Tung University, Taiwan 
2023-present    Professor, Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taiwan 

SELECTED PUBLICATIONS

1. Tsai YH, Wu PY, Chuang YC, Huang CY, Takeda H, Hibino H, Wu CC, *Cheng YF. Postnatal Slc26a4 gene therapy improves hearing and structural integrity in a hereditary hearing loss model . J Clin Invest. 2026 Feb 17:e193812. doi: 10.1172/JCI193812. Online ahead of print.
2. Wang AG, Huang CY, Cheng HC, Hung WC, *Cheng YF. Generation of an induced pluripotent stem cell (iPSC) line (IPSCi001-A), from a 40-year-old female patient with occult macular dystrophy carrying the c.133C > T mutation in the RP1L1 gene . Stem Cell Res. 2026 Mar:91:103902. doi: 10.1016/j.scr.2025.103902.
3. Hung SH, Xirasagar S, *Cheng YF, Lin HC, Chen CS. High Prevalence of Diabetes Mellitus among Patients with Fabry Disease in Taiwan: ACross-sectional Study. BMJ Open. 2025 May 31;15(5):e099735.
4. Yang TH, Lee HC,* Cheng YF, Lin HC, Chen CS. Sjögren’s syndrome increased risk of attempted suicide. Scientific Reports. 2025 Mar 18;15(1):9379. doi: 10.1038/s41598-025-92691-5.
5. Ho CH, Tsai CY, Chang CC, Hu CJ, Huang CY, Lu YC, Lin PH, Lin CH, Lin HI, OuYang CH, Hsu CJ, Liu TC, Chen YT, Chan YH, *Cheng YF, Wu CC. Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of the SLC26A4 c.919-2A>G Variant. Int J Mol Sci. 2025 May 22;26(11):4980. doi: 10.3390/ijms26114980.
6. Yang TH, *Cheng YF, Lin HC, Chen CS. Association between prior allergic rhinitis and Parkinson's disease. Parkinsonism Relat Disord. 2025 Oct:139:108013. doi: 10.1016/j.parkreldis.2025.108013.
7. Hung SH, Yang TH,* Cheng YF, Lin HC, Ho JD, Chen CS. Association of peripheral vestibular disorder with human papillomavirus infections. Eur Arch Otorhinolaryngol. 2025 Jul;282(7):3579-3585. doi: 10.1007/s00405-025-09283-2.
8. Yang TH, *Cheng YF, Lin HC, Chen CS. A population-based study on the associations of thyroid cancer with chronic periodontitis. J Periodontol. 2025 Apr;96(4):383-389. doi: 10.1002/JPER.24-0311
9. Yang TH, *Cheng YF, Lin HC, Chen CS. Prior chronic periodontitis is associated with chronic rhinosinusitis: A population-based case-control study. J Periodontol. 2025 Oct;96(10):1179-1186. doi: 10.1002/JPER.24-0744.
10. Cheng YF, Kempfle JS, Chiang H, Tani K, Wang Q, Chen S-H, Lenz D, Chen W-Y, Wu W, Petrillo M, Edge A (2025). Sox2 Interacts with Atoh1 and Huwe1 Loci to Regulate Atoh1 Transcription and Stability During Hair Cell Differentiation. PLoS Genetics. 2025 Jan 30;21(1):e1011573.
11. Huang CY, Tsai YH, Cheng YF, Wu PY, Chuang YC, Huang PY, Liu JS, CC Wu*, YF Cheng*. CRISPR/Cas9-mediated exon skipping to restore premature translation termination in a DFNB4 mouse model. Gene Therapy. 2024 Nov;31(11-12):531-540. (*Corresponding author) （封面故事）
12. Hung SH, Chang AH, Cheng YF*, Lin HC*, Chen CS*. Association of Young-Onset Dementia with Pre-Existing Peripheral Vestibular Disorders. J Alzheimers Dis. 2024;101(2):603-610. (*Corresponding author)
13. Yang TH, Chen CH, Cheng YF*, Lin HC*, Chen CS*. Association of Peripheral Vestibular Disorder with Diabetes: A Population-Based Study. J Pers Med. 2024 Jul 19;14(7):768. (*Corresponding author)
14. Hung SH, Xirasagar S, Cheng YF*, Lin HC*, Chen CS*. Association of Alzheimer's Disease With Peripheral Vestibular Disorder: A Case-Control Study. Laryngoscope. 2024 Nov;134(11):4730-4735. (*Corresponding author)
15. Hung SH, Xirasagar S, Dang LH, Viet-Nhi NK, Cheng YF*, Chen CS, Lin HC*. Prevalence of hearing loss, tinnitus, vertigo and sudden deafness among patients with polymyositis and dermatomyositis. Sci Rep. 2024 Mar 9;14(1):5774.  (*Corresponding author)
16. Yang TH, Xirasagar S, Cheng YF*, Chen CS, Lin HC*. Increased prevalence of peripheral vestibular disorder among patients with Fabry disease. Orphanet J Rare Dis. 2024 Mar 2;19(1):97. (*Corresponding author)
17. Yang TH, Xirasagar S, Cheng YF*, Chen CS*, Lin HC*. Increased prevalence of hearing loss, tinnitus and sudden deafness among patients with Sjögren's syndrome. RMD Open. 2024 Jan 19;10(1):e003308.  (*Corresponding author)
18. Hung SH, Xirasagar S, Dang LH, Chen YC, Cheng YF*, Chen CS*, Lin HC*. Trends in the incidence of peripheral vestibular disorders: a Nationwide population-based study. Front Neurol. 2023 Dec 12;14:1322199.  (*Corresponding author)
19. Yang TH, Xirasagar S, Cheng YF*, Chen CS*, Lin HC*. Does peripheral vestibular disorder increase the risk of attempted suicide: A retrospective cohort study. J Affect Disord. 2023 Nov 15;341:12-16. (*Corresponding author)
20. Chen CH, Hung KF, Huang CY, Leong JL, Chu YC, Chang CY, Wang ML, Chiou SH, Cheng YF*. Is N -acetylcysteine effective in treating patients with coronavirus disease 2019? A meta-analysis. J Chin Med Assoc. 2023 Mar 1;86(3):274-281.  (*Corresponding author)
21. Cheng YF, Xirasagar S, Kuo NW, Lin HC. Tinnitus and risk of attempted suicide: A one year follow-up study. J Affect Disord. 2023 Feb 1;322:141-145. 
22. Cheng YF, Xirasagar S, Chen CS, Niu DM, Lin HC. Association of Fabry Disease with Hearing Loss, Tinnitus, and Sudden Hearing Loss: A Nationwide Population-Based Study. J Clin Med. 2022; 11(24):7396. 
23. Lin HYH, Lai HS, Huang CY, Chen CH, Wu SL, Chu YC, Chen YF, Lai YH, Cheng YF*. Smartphone-bundled Earphones as Personal Sound Amplification Products in Adults with Sensorineural Hearing Loss. iScience. 2022 Nov 15;25(12):105436. (*Corresponding author)
24. Hung SH, Xirasagar S, Cheng YF*, Kuo NW, Lin HC*. Association of Chronic Kidney Disease with Prior Tinnitus: A Case–Control Study. J Clin Med. 2022; 11(24):7524. (*Corresponding author)
25. Cheng HL, Han JY, Zheng WZ, Cheng YF, Chu YC, Lin CM, Chiang MC, Liao WH, Lai YH. Objective Signal Analysis for Investigating Feasibility of Active Noise Cancellation in Hearing Screening. Sensors (Basel). 2022 Sep 27;22(19):7329.
26. Lu YC, Tsai YH, Chan YH, Hu CJ, Huang CY, Xiao R, Hsu CJ, Vandenberge LH, Wu CC*, Cheng YF*. Gene therapy with a synthetic adeno-associated viral vector improves audiovestibular phenotypes in Pjvk mutant mice. JCI Insight. 2022 Oct 24;7(20):e152941 (*Corresponding author) （封面故事）
27. Chen YC, Chu YC, Huang CY, Lee YT, Lee WY, Hsu CY, Yang AC*, Liao WH*, Cheng YF*. Smartphone-based artificial intelligence using a transfer learning algorithm for the detection and diagnosis of middle ear diseases : a retrospective deep learning study. EClinicalMedicine. 2022 Sep 7;51(9):101543 (*Corresponding author)
28. Huang PH, Xirasagar S, Chen JH, Cheng YF*, Kuo NW*, Lin HC*. Absence of Association of Tinnitus With Pre-existing Hypertension: A Population-based Study. Ann Otol Rhinol Laryngol. 2022 Aug 3:34894221115756. Epub ahead of print. PMID: 35923124. (*Corresponding author)
29. Leong JL, Chen CH, Huang CY, Cheng HL, Chu YC, Chang CY, Cheng YF*. Combination Therapy and Single-Modality Treatment for Acute Low-Tone Hearing Loss: A Meta-analysis with Trial Sequential Analysis. Brain Sci. 2022 Jun 12;(7):866. (*Corresponding author)
30. Chen CH, Huang CY, Cheng HL, Lin HYH, Chu YC, Chang CY, Lai YH, Wang MC, Cheng YF*. Comparison of personal sound amplification products and conventional hearing aids for patients with hearing loss: A systematic review with meta-analysis. EClinicalMedicine. 2022 Apr 7;46(4):101378. (*Corresponding author)
31. Chen CH, Huang CY, Cheng HL, Lin HH, Chu YC, Chang CY, Lai YH, Wang MC, Cheng YF*. Smartphone-Enabled versus Conventional Otoscopy in Detecting Middle Ear Disease: A Meta-Analysis. Diagnostics. 2022 Apr 13;12(4):972.  (*Corresponding author)
32. Hung SH, Xirasagar S, Kuang TMT, Chang WW, Cheng YF*, Kuo NW*, Lin HC*. Association of Age-Related Macular Degeneration with Prior Hyperthyroidism and Hypothyroidism: A Case-Control Study. J Pers Med. 2022 Apr 8;12(4):602. (*Corresponding author)
33. Lin HC, Xirasagar S, Wang CH, Cheng YF*, Yang TH*. Increased Risk of Major Depressive Disorder Following Tinnitus: A Population-Based Study. Front Neurol. 2022 Mar 21;13:836842. (*Corresponding author)
34. Ting KC, Chang CC, Huang CY, Chen YF, YF Cheng*. Are Electrocochleographic Changes an Early Sign of Cochlear Synaptopathy? A Prospective Study in Tinnitus Patients with Normal Hearing. Diagnostics. 2022 Mar 25;12(4): 802. (*Corresponding author)
35. Chang FL, Chen CH, Cheng HL, Chang CY, Leong JL, Chang YT, Cheng YF*, Liao WH*. Efficacy of Ventilation Tube Insertion with Palatal Repair for Otitis Media in Cleft Palate: Meta-Analysis and Trial Sequential Analysis. J Per Med. 2022 Feb 10;12(2):255. (*Corresponding author)
36. Cheng YF, Xirasagar S, Yang TH, Kuo N­­W, Lin HC. Association of hearing loss with land transport accidents: a nationwide population-based study. Int J Audiol. 2021 Nov 12:1-5
37. Cheng YF, Xirasagar S, Liu TC, Kuo NW, Lin HC. Ten-year trends in the incidence of microtia: a nationwide population-based study from Taiwan. Eur Arch Otorhinolaryngol. 2021 Nov;278(11):4315-4319
38. Hu CJ, Lu YC, Tsai YH, Lin PH, Lee YS, Yu IS, Lin SW, Liu TC, Hsu CJ, Yang TH, Cheng YF*, Wu CC*. Insights into phenotypic differences between humans and mice with p.T721M and other C-terminal variants of the SLC26A4 gene. Sci Rep. 2021 Oct 25;11(1):20983. (*Corresponding author)
39. Chen CH, Lin HYH, Wang MC, Chang CY, Huang CY, Cheng YF*. Diagnostic Accuracy of Smartphone-based Audiometry for Hearing Loss Detection: A Meta‐analysis. JMIR Mhealth Uhealth. 2021 Sep 10;9(9):e28378. (*Corresponding author)
40. Chen CH, Huang CY, Lin HYH, Wang MC, Huang, Cheng YF*. Association of Sodium Thiosulfate with Risk of Ototoxic Effects from Platinum-based Chemotherapy: A Systematic Review and Meta-analysis. JAMA Network Open. 2021 Aug 2 ;4(8):e2118895. (*Corresponding author)
41. Ridge SE, Chari DA, Kozin ED, Remenschneider AK, Adunka OF, Aristegui M, Chang WT, Cheng YF, et al. International Survey of Operative Practices for Otologists and Neurotologists During the COVID-19 Crisis. Otol & Neurotol. 2021 Sep 1;42(8), 1275–1284. 
42. Hsueh CY, Huang CY, Yang CF, Chang CC, Lin WS, Cheng HL, Wu SL, Cheng YF*, Niu DM*. Hearing characteristics of infantile‑onset Pompe disease after early enzyme‑replacement therapy. Orphanet J Rare Dis. 2021 Aug 5;16(1):348 (*Corresponding author)
43. Cheng YF, Xirasagar S, Yang TH, Wu CS, Kuo NW,Shia BC, Lin HC. Risk of Early-Onset Dementia Among Persons with Tinnitus – A Retrospective Case-Control Study. Sci Rep. 2021 Jun 28;11(1):13399.
44. Hu CJ, Lu YC, Yang TH, Chan YH, Tsai CY, Yu IS, Lin SW, Liu TC, Cheng YF*, Wu CC*, Hsu CJ*. Toward the Pathogenicity of the SLC26A4 p.C565Y Variant Using a Genetically Driven Mouse Model. Int J Mol Sci. 2021 Mar; 22(6): 2789 (*Corresponding author)
45. Cheng YF, Xirasagar S, Kuo NW, Chung SD, Lin HC. Association of Erectile Dysfunction with Tinnitus: A Nationwide Population-based Study. Sci Rep. 2021 Mar 26;11(1):6982.
46. Cheng YF, Xirasagar S, Yang TH, Wu CS, Kao YW, Lin HC. A Population-Based Case-control Study of the Association between Cervical Spondylosis and Tinnitus. Int J Audiol. 2021 Mar;60(3):227-231.
47. Chen CH, Huang CY, Chang CY, Cheng YF*. Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis. Brain Sci. 2020 Dec 2;10(12):E931. (*Corresponding author)
48. Chen YC, Huang CY, Lee YT, Wu CH, Chang SK, Cheng HL, Chang PH, Niu DM*, Cheng YF*. Audiological and otologic manifestations of glutaric aciduria type I. Orphanet J Rare Dis. 2020 Dec 1;15(1):337. (*Corresponding author)
49. Lin HYH, Chu YC, Lai YH, Cheng HL, Lai FP, Cheng YF*, Liao WH. A Smartphone-Based Approach to Screening for Sudden Sensorineural Hearing Loss: A Cross-sectional Validity Study. JMIR Mhealth Uhealth. 2020 Nov 11;8(11):e23047. (*Corresponding author)
50. Cheng YF, Tsai YH, Huang CY, PC Chang, YH Lee, Lu YC, Hsu CC, Wu CC. Generation and pathological characterization of a transgenic mouse model carrying a missense PJVK mutation. Biochem Biophy Res Commun. 2020 Nov 19;532(4):675-681
51. Hu CJ, Lu YC, Tsai YH, Cheng HY, Takeda H, Huang CY, Xiao R, Hsu CJ, Tsai JW, Vandenberghe LH, Wu CC, Cheng YF*. Efficient in utero gene transfer to the mammalian inner ears by the synthetic adeno-associated viral vector Anc80L65. Mol Ther Methods Clin Dev. 2020 Jun 24;18:493-500. (*Corresponding author) （封面故事）
52. Cheng YF, Xirasagar S, Yang TH, Wu CS, Kao YW, Shia BC, Lin HC. Increased Risk of Tinnitus Following a Trigeminal Neuralgia Diagnosis: A One-year Follow-up Study. 2020 May 6;21(1):46. J Headache Pain. 2020 May 6;21(1):46.
53. Chen YC, Huang CY, Kuo YJ, Cheng HL, Cheng YF*, Liao WH*. Developing a novel meatal areolar tissue autograft for minimally invasive tympanoplasty. J Chin Med Assoc. 2020 Oct;83(10):956-961 (*Corresponding author)
54. Huang CY, Tsai YH, Tsai YC, Chan YC, Chiou SH, Wu CC, Cheng YC*. Establishment of an induced pluripotent stem cell (iPSC) line from a 7-year-old male patient with profound hearing loss carrying c.235delC in GJB2 gene. Stem Cell Research, 2020 May;45:101795. (*Corresponding author)
55. Cheng YF, Chan YH, Hu CJ, Lu YC, Fujioka M, Okano H, Hsu CJ, Chang KH, Wu CC. Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred Syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation. Stem Cell Res. 2019 Oct;40:101524.
56. Cheng YF, Yang TH, Wu CS, Lin HC. A Population-based Time Trend Study in the Incidence of Malignant Otitis Externa. Clin Otolaryngol. 2019 Sep;44(5):851-855
57. Shen J, Oza AM, Del Castillo I, Duzkale H, Matsunaga T, Pandya A, Kang HP, Mar-Heyming R, Guha S, Moyer K, Lo C, Kenna M, Alexander JJ, Zhang Y, Hirsch Y, Luo M, Cao Y, Wai Choy K, Cheng YF, et al. .Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel. Genet Med. 2019 Nov;21(11):2442-2452.
58. Cheng YF, Tong M, Edge ASB. “Destabilization of Atoh1 by E3 ubiquitin ligase Huwe1 and casein kinase 1 is essential for normal sensory hair cell development”. J Bio Chem. 2016;291:21096-21109