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細胞治療轉譯研究室

TEL: +886-2-2871-2121 #24184

E-mail: [email protected]

主持人:楊逸萍
《現職》

臺北榮民總醫院醫學研究部副研究員

臺北榮民總醫院細胞治療核心實驗室管理人

《學歷》

臺北榮民總醫院醫學研究部高級助理研究員

國防醫學院神經外科博士後研究員

國立陽明大學臨床醫學研究所博士

國立陽明大學生物化學研究所碩士
《研究興趣與方向》
  1. 幹細胞多能分化與移植研究
  2. 利用幹細胞建構疾病模型探討作用機轉及藥物篩選
  3. 轉譯醫學及細胞治療臨床應用
《執行計畫》

國科會

院內計畫

《獲獎》

2024 第21屆國家新創獎學研新創獎

2023 第20屆國家新創獎學研新創獎

2023 臺北生技獎跨域卓越優等獎

2021 臺北生技獎跨域卓越優等獎

2021 未來科技獎

2021 醫事人員創新(改良)獎其他人員組,第二名

《近期研究著作》
  1. Yang YC, Chien Y, Yarmishyn AA, Lim LY, Tsai HY, Kuo WC, Tsai PH, Yang SH, Hong SI, Chen SJ, Hwang DK, Yang YP, Chiou SH. (2024 Jun). Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation. Journal of Advanced Research, 60:141-157.
  2. Chien Y, Huang XY, Yarmishyn AA, Chien CS, Liu YH, Hsiao YJ, Lin YY, Lai WY, Huang SC, Lee MS, Chiou SH, Yang YP, Chiou GY. (2024 Jul). Paracrinal regulation of neutrophil functions by coronaviral infection in iPSC-derived alveolar type II epithelial cells. Virus Research, 345:199391.
  3. Yang YP, Chang YL, Chiou GY, Lee MS, Wu YR, Chen PW, Lin YY, Lai WY, Liu YH, Hwang DK, Chien Y. (2024 Mar). Dysregulation of the circRNA_0087207/miR-548c-3p/PLSR1-TGFB2 axis in Leber hereditary optic neuropathy in vitro. Journal of the Chinese Medical Association. 87(3):261-266.
  4. Peng SY, Chen CY, Chen H, Yang YP, Wang ML, Tsai FT, Chien CS, Weng PY, Tsai ET, Wang IC, Hsu CC, Lin TC, Hwang DK, Chen SJ, Chiou SH, Chiao CC, Chien Y. (2024 Sep). Inhibition of angiogenesis by the secretome from iPSC-derived retinal ganglion cells with Leber's hereditary optic neuropathy-like phenotypes. Biomedicine & Pharmacotherapy, 178:117270.
  5. Chien Y, Hsiao YJ, Chou SJ, Lin TY, Yarmishyn AA, Lai WY, Lee MS, Lin YY, Lin TW, Hwang DK, Lin TC, Chiou SH, Chen SJ, Yang YP. (2022 Dec). Nanoparticles-mediated CRISPR-Cas9 gene therapy in inherited retinal diseases: applications, challenges, and emerging opportunities. Journal of Nanobiotechnology, 3;20(1):511.
  6. Yang YP, Lai WY, Lin TW, Lin YY, Chien Y, Tsai YC, Tai HY, Wang CL, Liu YY, Huang PI, Chen YW, Lo WL, Wang CY. (2022 Jun). Autophagy reprogramming stem cell pluripotency and multiple-lineage differentiation. Journal of the Chinese Medical Association,85(6):667-671.
  7. Yang YP, Lee AC, Lin LT, Chen YW, Huang PI, Ma HI, Chen YC, Lo WL, Lan YT, Fang WL, Wang CY, Liu YY, Hsu PK, Lin WC, Li CP, Chen MT, Chien CS, Wang ML. (2022 Jan). Strategic Decoy Peptides Interfere with MSI1/AGO2 Interaction to Elicit Tumor Suppression Effects. Cancers (Basel), 4(3):505.
  8. Ishola AA, Chien CS, Yang YP, Chien Y, Yarmishyn AA, Tsai PH, Chen JC, Hsu PK, Luo YH, Chen YM, Liang KH, Lan YT, Huo TI, Ma HI, Chen MT, Wang ML, Chiou SH. (2022 Jan). Oncogenic circRNA C190 Promotes Non-Small Cell Lung Cancer via Modulation of the EGFR/ERK Pathway. Cancer Research, 2022 Jan 1;82(1):75-89.
  9. Yang YP, Chien CS, Yarmishyn AA, Chan MS, Lee AC, Chen YW, Huang PI, Ma HI, Lo WL, Chien Y, Lin WC, Wang ML, Chen MT. (2021, Apr). Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression. Cancers. 13(8):1799.
  10. Yang YP, Nguyen PNN, Ma HI, Ho WJ, Chen YW, Chien Y, Yarmishyn AA, Huang PI, Lo WL, Wang CY, Liu YY, Lee YY, Lin CM, Chen MT, Wang ML. (2019, May). Tumor Mesenchymal Stromal Cells Regulate Cell Migration of Atypical Teratoid Rhabdoid Tumor through Exosome-mediated miR155/SMARCA4 Pathway. Cancers, 11(5):720. (IF=4.5;RANK=78/322; ONCOLOGY ) (共同第一作者)

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