Department of Chest Medicine ,Taipei veterans general hospital

:::

劉嘉仁 (Chia-Jen Liu)

Return Appointment First Appointment

[Profile]

[Publications]

Bustoros M¹, Sklavenitis-Pistofidis R¹, Kapoor P¹, Liu CJ¹, Kastritis E, Zanwar S, Fell G, Abeykoon JP, Hornburg K, Neuse CJ, Marinac CR, Liu D, Soiffer J, Gavriatopoulou M, Boehner C, Cappuccio JM, Dumke H, Reyes K, Soiffer RJ, Kyle RA, Treon SP, Castillo JJ, Dimopoulos MA, Ansell SM, Trippa L, Ghobrial IM. Progression risk stratification of Asymptomatic Waldenström Macroglobulinemia. Journal of Clinical Oncology. 2019 Jun; 37(16):1403-1411. (IF: 43.400; Oncology 6/328; 1.8%) (co-first author)
Chao TF¹, Liu CJ¹, Tuan TC, Chen SJ, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Chen TJ, Chiang CE, Chen SA. Rate-Control Treatment and Mortality in Atrial Fibrillation. Circulation. 2015 Oct; 132(17):1604-12. (IF: 38.700; Cardiac & Cardiovascular Systems 2/231; 0.9%) (co-first author)
Chao TF¹, Liu CJ¹, Liao JN, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chung FP, Chen TJ, Lip GY, Chen SA. Use of Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation Who Have a History of Intracranial Hemorrhage. Circulation. 2016 Apr; 19;133(16):1540-7. (IF: 38.700; Cardiac & Cardiovascular Systems 2/231; 0.9%) (co-first author)
Lai TY, Hu YW, Wang TH, Chen JP, Shiau CY, Huang PI, Lai IC, Tseng LM, Huang N, Liu CJ*. Association of Radiation Dose to Cardiac Substructures with Major Ischaemic Events Following Breast Cancer Radiotherapy. European Heart Journal. 2023 Dec; 44(45):4796-4807. (IF: 35.700; Cardiac & Cardiovascular Systems 3/231; 1.3%) (corresponding author)
Manier S¹, Liu CJ¹, Avet-Loiseau H, Park J, Shi J, Campigotto F, Salem KZ, Huynh D, Glavey SV, Rivotto B, Sacco A, Roccaro AM, Bouyssou J, Minvielle S, Moreau P, Facon T, Leleu X, Weller E, Trippa L, Ghobrial IM. Prognostic role of circulating exosomal miRNAs in multiple myeloma. Blood. 2017 Apr; 129(17):2429-2436. (IF: 23.100; Hematology 2/99; 2.0%) (co-first author)
Chao TF¹, Liu CJ¹, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chen TJ, Lip GY, Chen SA. Using the CHA2DS2-VASc Score for Refining Stroke Risk Stratification in 'Low-Risk' Asian Patients With Atrial Fibrillation. Journal of the American College of Cardiology. 2014 Oct; 21;64(16):1658-65. (IF: 22.300; Cardiac & Cardiovascular Systems 4/231; 1.7%) (co-first author)
Chao TF¹, Liu CJ¹, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chen TJ, Lip GY, Chen SA. Should Atrial Fibrillation Patients With 1 Additional Risk Factor of the CHA2DS2-VASc Score (Beyond Sex) Receive Oral Anticoagulation?. Journal of the American College of Cardiology. 2015 Feb; 65(7):635-42. (IF: 22.300; Cardiac & Cardiovascular Systems 4/231; 1.7%) (co-first author)
Wang YP¹, Liu CJ¹, Hu YW, Chen TJ, Lin YT*, Fung CP. Risk of cancer among patients with herpes zoster infection: a population-based study. Canadian Medical Association Journal. 2012 Oct; 16;184(15):E804-9. (IF: 12.200; Medicine, General & Internal 10/332; 3.0%) (co-first author)
Su VY¹, Liu CJ¹, Wang HK, Wu LA, Chang SC, Perng DW, Su WJ, Chen YM, Lin EY, Chen TJ, Chou KT. Sleep apnea and risk of pneumonia: a nationwide population-based study. Canadian Medical Association Journal. 2014 Apr; 186(6):415-21. (IF: 12.200; Medicine, General & Internal 10/332; 3.0%) (co-first author)
Su VY¹, Liu CJ¹, Lan MY, Chen YM, Su KC, Lee YC, Chen TJ, Chou KT*. Allergic rhinitis and risk of erectile dysfunction – A nationwide population-based study. Allergy. 2013 Apr; 68(4):440-5. (IF: 12.000; Allergy 1/40; 2.5%) (co-first author)
Chien CY, Lee YL, Jeng MJ, Liu CJ*. Using Computed Tomography to Evaluate Anatomic Landmarks in Taiwanese Trauma Patients for Insertion of Resuscitative Endovascular Balloon Occlusion of the Aorta: A Retrospective Cohort Study. International Journal of Surgery. 2024 Sep; 110(12):7900-7908. (IF: 10.300; Surgery 3/314; 1.0%) (corresponding author)
Chao TF¹, Liu CJ¹, Chen SJ, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Wu TJ, Tsao HM, Chen TJ, Chen SA*. Atrial fibrillation and the risk of ischemic stroke - does it still matter in patients with a CHA2DS2-VASc score of 0 or 1?. Stroke. 2012 Oct; 43(10):2551-5. (IF: 8.900; Clinical Neurology 10/286; 3.5%) (co-first author)
Kuan AS, Teng CJ, Wu HH, Su VY, Chen YT, Chien SH, Yeh CM, Hu LY, Chen TJ, Tzeng CH, Liu CJ*. Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study. BMC Medicine. 2014 Mar; 12(1):53. (IF: 8.300; Medicine, General & Internal 21/332; 6.3%) (corresponding author)
Chen CY¹, Liu CJ¹, Feng JY, Loong CC, Liu C, Hsia CY, Hu LY, Lin NC, Hu YW, Yeh CM, Chen TJ, Yang CC. Incidence and Risk Factors for Tuberculosis After Liver Transplantation in an Endemic Area: A Nationwide Population-Based Matched Cohort Study. American Journal of Transplantation. 2015 Aug; 15(8):2180-7. (IF: 8.200; Surgery 6/314; 1.9%) (co-first author)
Lai TY, Hu YW, Wang TH, Chen JP, Shiau CY, Huang PI, Lai IC, Liu YM, Huang CC, Tseng LM, Huang N, Liu CJ*. Estimating the risk of major adverse cardiac events following radiotherapy for left breast cancer using a modified generalized Lyman normal-tissue complication probability model. Breast. 2024 Oct; 77:103788. (IF: 7.900; Obstetrics & Gynecology 4/141; 2.8%) (corresponding author)
Wang YP¹, Liu CJ¹, Chen TJ, Lin YT, Fung CP. Proton pump inhibitor use significantly increases the risk of cryptogenic liver abscess: a population-based study. Alimentary Pharmacology & Therapeutics. 2015 Jun; 41(11):1175-81. (IF: 6.700; Pharmacology & Pharmacy 26/352; 7.4%) (co-first author)
Chao TF¹, Liu CJ¹, Tuan TC, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Chen TJ, Chiang CE, Hsieh MH, Lip GY, Chen SA. Impact on Outcomes of Changing Treatment Guideline Recommendations for Stroke Prevention in Atrial Fibrillation: A Nationwide Cohort Study. Mayo Clinic Proceedings. 2016 May; 91(5):567-74. (IF: 6.700; Medicine, General & Internal 26/332; 7.8%) (co-first author)
Lin YT¹, Liu CJ¹, Chen TJ, Chen TL, Yeh YC, Wu HS, Tseng CP, Wang FD, Tzeng CH, Fung CP*. Pyogenic liver abscess as the initial manifestation of underlying hepatocellular carcinoma. American Journal of Medicine. 2011 Dec; 124(12):1158-64. (IF: 5.300; Medicine, General & Internal 33/332; 9.9%) (co-first author)
Shiao TH¹, Liu CJ¹, Luo JC, Su KC, Chen YM, Chen TJ, Chou KT*, Shiao GM, Lee YC. Sleep apnea and risk of peptic ulcer bleeding: A nationwide population-based study. American Journal of Medicine. 2013 Mar; 126(3):249-255.e1. (IF: 5.300; Medicine, General & Internal 33/332; 9.9%) (co-first author)
Lee PC, Hu YW, Hung MH, Chen CC, Lin HC, Lee FY, Hung YP, Yi-Fong Su V, Yen SH, Tzeng CH, Chiou TJ, Liu CJ*. The risk of cancer in patients with benign anal lesions: A nationwide population-based study. American Journal of Medicine. 2013 Dec; 126(12):1143.e9-18. (IF: 5.300; Medicine, General & Internal 33/332; 9.9%) (corresponding author)
Lee PC, Hu YW, Hu LY, Chen SC, Chien SH, Shen CC, Yeh CM, Chen CC, Lin HC, Yen SH, Tzeng CH, Chen TJ, Liu CJ*. Risk of Cancer in Patients with Cholecystitis: A Nationwide Population-Based Study. American Journal of Medicine. 2015 Feb; 128(2):185-91. (IF: 5.300; Medicine, General & Internal 33/332; 9.9%) (corresponding author)
Hu LY, Ku FC, Wang YP, Shen CC, Hu YW, Yeh CM, Chen PM, Chiang HL, Lu T, Chen TJ, Teng CJ, Liu CJ*. Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study. Supportive Care in Cancer. 2015 Mar; 23(3):733-40. (IF: 3.000; Rehabilitation 17/175; 9.7%) (corresponding author)
Tsai CK, Yeh CM, Hsu TL, Li CJ, Chian T, Hsiao LT, Liu YC, Wang HY, Ko PS, Chen PM, Liu JH, Gau JP, Liu CJ*. Underweight as a risk factor of mortality in patients with newly diagnosed multiple myeloma. Supportive Care in Cancer. 2021 Jul; 29(7):3991-3999. (IF: 3.000; Rehabilitation 17/175; 9.7%) (corresponding author)
Chao TF¹, Liu CJ¹, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Liao JN, Chung FP, Chen TJ, Lip GYH, Chen SA. Oral Anticoagulation in Very Elderly Patients With Atrial Fibrillation: A Nationwide Cohort Study. Circulation. 2018 Jul; 138(1):37-47. (IF: 38.700; Cardiac & Cardiovascular Systems 2/231; 0.9%)
Chao TF¹, Liu CJ¹, Liao JN, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chung FP, Chen TJ, Lip GY, Chen SA. Response by Chao et al to Letters Regarding Article, "Use of Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation Who Have a History of Intracranial Hemorrhage". Circulation. 2016 Sep; 134(11):e230-1. (IF: 38.700; Cardiac & Cardiovascular Systems 2/231; 0.9%)
Tsai CF, Liu CJ, Chen TJ, Chu CJ, Lin HC, Lee FY, Su TP, Lu CL. Increased incidence of orthopedic fractures in cirrhotic patients: A nationwide population-based study. Journal of Hepatology. 2013 Apr; 58(4):706-14. (IF: 33.000; Gastroenterology & Hepatology 3/148; 2.0%)
Zavidij O, Haradhvala NJ, Mouhieddine TH, Pistofidis RS, Cai S, Reidy M, Rahmat M, Flaifel A, Ferland B, Su NK, Agius MP, Park J, Manier S, Bustoros M, Huynh D, Capelletti M, Berrios B, Liu CJ, He MX, Braggio E, Fonseca R, Maruvka YE, Guerriero JL, Goldman M, Allen EMV, McCarroll SA, Azzi J, Getz G, Ghobrial IM. Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma. Nature Cancer. 2020 Apr; 1:493-506. (IF: 28.500; Oncology 11/328; 3.4%)
Sklavenitis-Pistofidis R, Capelletti M, Liu CJ, Reidy M, Zavidij O, Huynh D, Henrick P, Savell A, Reyes K, Rivotto B, Bustoros M, Perilla-Glen A, Trippa L, Castillo JJ, Treon SP, Ghobrial IM. Bortezomib overcomes the negative impact of CXCR4 mutations on survival of Waldenstrom's Macroglobulinemia patients. Blood. 2018 Dec; 132(24):2608-2612. (IF: 23.100; Hematology 2/99; 2.0%)
Wang KL, Liu CJ, Chao TF, Huang CM, Wu CH, Chen SJ, Chen TJ, Lin SJ, Chiang CE. Statins, risk of diabetes, and implications on outcomes in the general population. Journal of the American College of Cardiology. 2012 Oct; 60(14):1231-8. (IF: 22.300; Cardiac & Cardiovascular Systems 4/231; 1.7%)
Chao TF, Wang KL, Liu CJ, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chung FP, Liao JN, Chen TJ, Chiang CE, Lip GY, Chen SA. Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation: A Nationwide Cohort Study From Taiwan. Journal of the American College of Cardiology. 2015 Sep; 22;66(12):1339-47. (IF: 22.300; Cardiac & Cardiovascular Systems 4/231; 1.7%)
Chao TF, Lip GYH, Liu CJ, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Liao JN, Chung FP, Chen TJ, Chen SA. Relationship of Aging and Incident Comorbidities to Stroke Risk in Patients With Atrial Fibrillation. Journal of the American College of Cardiology. 2018 Jan; 71(2):122-132. (IF: 22.300; Cardiac & Cardiovascular Systems 4/231; 1.7%)
Wang KL, Liu CJ, Chiang CE. Reply: To PMID 22884288. Journal of the American College of Cardiology. 2013 Mar; 61(9):989-90. (IF: 22.300; Cardiac & Cardiovascular Systems 4/231; 1.7%)
Chao TF, Liu CJ, Chen SA. Reply: One More "C" for CHA2DS2-VASc Score. Journal of the American College of Cardiology. 2015 Apr; 65(15):1603-4. (IF: 22.300; Cardiac & Cardiovascular Systems 4/231; 1.7%)
Lai CC, Wang SH, Chen WS, Liu CJ, Chen TJ, Lee PC, Chang YS. Increased risk of osteoporotic fractures in patients with systemic sclerosis: a nationwide population-based study. Annals of the Rheumatic Diseases. 2015 Jul; 74(7):1347-52. (IF: 20.600; Rheumatology 2/58; 3.4%)
Manier S, Park J, Capelletti M, Bustoros M, Freeman SS, Ha G, Rhoades J, Liu CJ, Huynh D, Reed SC, Gydush G, Salem KZ, Rotem D, Freymond C, Yosef A, Perilla-Glen A, Garderet L, Van Allen EM, Kumar S, Love JC, Getz G, Adalsteinsson VA, Ghobrial IM. Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma. Nature Communications. 2018 Apr; 9(1):1691. (IF: 15.700; Multidisciplinary Sciences 10/136; 7.4%)
Mouhieddine TH, Sperling AS, Redd R, Park J, Leventha M, Gibson CJ, Manier S, Nassar AH, Capelletti M, Huynh D, Bustoros M, Sklavenitis-Pistofidis R, Tahri S, Hornburg K, Dumke H, Itani MM, Boehner CJ, Liu CJ, AlDubayan SH, Reardon B, Allen EMV, Keats JJ, Stewart C, Mehr S, Auclair D, Schlossman RL, Munshi NC, Anderson KC, Steensma DP, Laubach JP, Richardson PG, Ritz J, Ebert BL, Soiffer RJ, Trippa L, Getz G, Neuberg DS, Ghobrial IM. Clonal Hematopoiesis Is Associated With Adverse Outcomes in Multiple Myeloma Patients Undergoing Transplant. Nature Communications. 2020 Jun; 11(1):2996. (IF: 15.700; Multidisciplinary Sciences 10/136; 7.4%)
Zhao J, Lin SY, Attias R, Mathews L, Engel C, Larghero G, Vremenko D, Kao TW, Lee TH, Wang YH, Tsai CC, Marostica E, Lo YC, Meredith D, Ligon KL, Arnaout O, Roetzer-Pejrimovsky T, Lin SC, Shih NN, Chaisuriya N, Cook DJ, Chiang JH, Liu CJ, Woehrer A, Golden JA, Nasrallah MP, Yu KH. Uncertainty-Aware Ensemble of Foundation Models Differentiates Glioblastoma from its Mimics – A Multi-Center Study. Nature Communications. 2025 Sep; 16(1):8341. (IF: 15.700; Multidisciplinary Sciences 10/136; 7.4%)
Wang YP, Chen YT, Tsai CF, Li SY, Luo JC, Wang SJ, Tang CH, Liu CJ, Lin HC, Lee FY, Chang FY, Lu CL*. Short-term use of serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding. American Journal of Psychiatry. 2014 Jan; 171(1):54-61. (IF: 14.700; Psychiatry 5/288; 1.7%)
Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA Jr, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Science Translational Medicine. 2017 May; 10;9(389). (IF: 14.700; Medicine, Research & Experimental 3/195; 1.5%)
Ou SM, Chen YT, Chao PW, Lee YJ, Liu CJ, Yeh CM, Chen TJ, Chen TW, Yang WC, Li SY. Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients. Kidney International. 2013 Jul; 84(1):198-205. (IF: 12.600; Urology & Nephrology 5/133; 3.8%)
Liao JN, Chao TF, Liu CJ, Wang KL, Chen SJ, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chung FP, Chen TJ, Chen SA. Incidence and risk factors for new-onset atrial fibrillation among patients with end-stage renal disease undergoing renal replacement therapy. Kidney International. 2015 Jun; 87(6):1209-15. (IF: 12.600; Urology & Nephrology 5/133; 3.8%)
Mösges R, Hellmich M, Su VY, Chou KT, Liu CJ. Increased mortality in AR patients?. Allergy. 2013 Sep; 68(9):1209-10. (IF: 12.000; Allergy 1/40; 2.5%)
Hsieh PY, Liu CJ, Teng CJ. Immortal time bias in retrospective analysis: comment on 'Efficacy and safety of long-term treatment with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma'. Blood Cancer Journal. 2015 Feb; 27;5:e283. (IF: 11.600; Oncology 24/328; 7.3%)
Takagi S, Tsukamoto S, Park J, Johnson KE, Kawano Y, Moschetta M, Liu CJ, Mishima Y, Kokubun K, Manier S, Salem KZ, Huynh D, Sacco A, Forward J, Roccaro AM, Battinelli EM, Ghobrial IM. Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation. Clinical Cancer Research. 2018 May; 24(10):2430-2439. (IF: 10.200; Oncology 29/328; 8.8%)
Laubach JP, Liu CJ, Raje NS, Yee AJ, Armand P, Schlossman RL, Rosenblatt J, Hedlund J, Martin MG, Reynolds CH, Shain K, Zackon I, Stampleman L, Henrick P, Rivotto BJ, Hornburg K, Dumke H, Chuma S, Savell A, Handisides D, Kroll S, Anderson KC, Richardson PG, Ghobrial IM. A Phase 1/2 Study of evofosfamide, A Hypoxia-Activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma. Clinical Cancer Research. 2019 Jan; 25(2):478-486. (IF: 10.200; Oncology 29/328; 8.8%)
Ghobrial IM, Liu CJ, Redd RA, Perez RP, Baz R, Zavidij O, Sklavenitis-Pistofidis R, Richardson PG, Anderson KC, Laubach J, Henrick P, Savell A, Reyes K, Hornburg K, Chuma S, Sabbatini P, Robbins MD, Becker PS. A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma. Clinical Cancer Research. 2020 Jan; 26(2):344-353. (IF: 10.200; Oncology 29/328; 8.8%)
Chao TF, Liu CJ, Tuan TC, Chen TJ, Hsieh MH, Lip GYH, Chen SA. Lifetime Risks, Projected Numbers and Adverse Outcomes in Asian Patients with Atrial Fibrillation: A Report from the Taiwan Nationwide AF Cohort Study. Chest. 2018 Feb; 153(2):453-466. (IF: 9.200; Respiratory System 6/108; 5.6%)
Chao TF, Lip GY, Liu CJ, Tuan TC, Chen SJ, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Chen TJ, Chiang CE, Chen SA. Validation of a Modified CHA2DS2-VASc Score for Stroke Risk Stratification in Asian Patients With Atrial Fibrillation: A Nationwide Cohort Study. Stroke. 2016 Oct; 47(10):2462-9. (IF: 8.900; Clinical Neurology 10/286; 3.5%)
Chao TF, Chen SA, Liu CJ. Response to letter regarding article, "Atrial fibrillation and the risk of ischemic stroke--does it still matter in patients with a CHA2DS2-VASc score of 0 or 1?". Stroke. 2013 Apr; 44(4):e39. (IF: 8.900; Clinical Neurology 10/286; 3.5%)
Chu CH, Liu CJ, Lin LY, Chen TJ, Wang SJ. Migraine is associated with an increased risk for benign paroxysmal positional vertigo: a nationwide population-based study. Journal of Headache And Pain. 2015 Dec; 16(1):547. (IF: 7.900; Clinical Neurology 15/286; 5.2%)
Kuo SC, Chen YT, Lee YT, Fan NW, Chen SJ, Li SY, Liu CJ, Chen TL, Chen TJ, Fung CP. Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study. Clinical Infectious Diseases. 2014 Jan; 58(2):197-203. (IF: 7.300; Infectious Diseases 8/137; 5.8%)
Chu SY, Chen YJ, Liu CJ, Tseng WC, Lin MW, Hwang CY, Chen CC, Lee DD, Chen TJ, Chang YT, Wang WJ, Liu HN. Increased risk of acute myocardial infarction in systemic sclerosis: A nationwide population-based study. American Journal of Medicine. 2013 Nov; 126(11):982-8. (IF: 5.300; Medicine, General & Internal 33/332; 9.9%)
Chen PM, Chen SC, Liu CJ, Hung MH, Tsai CF, Hu YW, Chen MH, Shen CC, Su TP, Yeh CM, Lu T, Chen TJ, Hu LY. The association between prostate cancer and mood disorders: a nationwide population-based study in Taiwan. International Psychogeriatrics. 2015 Mar; 27(3):481-90. (IF: 4.300; Gerontology 3/48; 6.3%)
Chiang HL, Liu CJ, Hu YW, Chen SC, Hu LY, Shen CC, Yeh CM, Chen TJ, Gau SS. Risk of Cancer in Children, Adolescents, and Young Adults with Autistic Disorder. Journal of Pediatrics. 2015 Feb; 166(2):418-423. (IF: 3.500; Pediatrics 19/191; 9.9%)